局限期小细胞肺癌化疗及放疗联合化疗的疗效课件.ppt
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1、局限期小细胞肺癌化疗及放疗联合化疗的疗效,胡玉林 崔亚利 王明智 崔守仁 王瑞芝 高永君 杨雁飞无锡市第四人民医院,局限期小细胞肺癌化疗及放疗联合化疗的疗效,1,局限期小细胞肺癌化疗及放疗联合化疗的疗效胡玉林 崔亚利,Long-term results of chemotherapy alone or combined with radiation therapy for limited stage small cell lung cancer.,HU Yulin, CUI Yali, WANG Mingzhi,CUI Shouren, WANG Ruizhi, GAO Yongjun, Ya
2、ng Yanfei.,局限期小细胞肺癌化疗及放疗联合化疗的疗效,2,Long-term results of chemother,Objective To evaluate therapeutic outcome of limited stage small cell lung cancer treated with chemotherapy alone or combined with radiation therapy with different doses.,局限期小细胞肺癌化疗及放疗联合化疗的疗效,3,Objective To evaluate therapeu,Methods A
3、retrospective analysis was performed in 128 Limited-stage small cell lung cancer patients who were treated with three different ways of therapy, from February 1988 to March 1998 in Heilongjiang Provincial Cancer Hospital.,局限期小细胞肺癌化疗及放疗联合化疗的疗效,4,Methods A retrospective analy,All patients were patholo
4、gically proved. 42 patients received chemotherapy alone (C), 48 patients were treated by interdigitating chemoradiotherapy (IDG) and other 38 patients received concurrent chemoradiotherapy (CON).,局限期小细胞肺癌化疗及放疗联合化疗的疗效,5,All patients were pathological,Thoracic radiation, 20 patients received 45Gy(45Gy
5、 group),23 patients were given to 60Gy(60Gy group), 43 patients were given to 45Gy 60Gy.,局限期小细胞肺癌化疗及放疗联合化疗的疗效,6,Thoracic radiation, 20 patient,Results The 3-year survival rates of CON group, IDG group and C group were 23.6% , 20.8% and 4.7% respectively. There was significant difference between CON
6、group, IDG group and C group(x2=6.02,p0.05). Loco-regional recurrence rate (55%) was more frequent in 45GY group compared to 60GY group (8.7%).,局限期小细胞肺癌化疗及放疗联合化疗的疗效,7,Results The 3-year survival ra,Conclusion The chemotherapy combined radiotherapy may improve the patients survival .Dose of thoracic
7、radiation had significant effect on the loco-regional recurrence.,局限期小细胞肺癌化疗及放疗联合化疗的疗效,8,Conclusion The chemotherapy c,小细胞肺癌(SCLC)占肺癌的20%,发展快恶性程度高。长期以来关于局限期SCLC的治疗原则一直存在着争议。近年来研究结果显示联合放射治疗和化疗成为局限期SCLC的标准治疗方案。,局限期小细胞肺癌化疗及放疗联合化疗的疗效,9,小细胞肺癌(SCLC)占肺癌的20%,发展快恶性程度高。长期,但几种联合治疗方案同步进行、交替进行何为最佳方案,放射治疗的最佳时间、最佳
8、放射治疗剂量尚无一致观点。我们对黑龙江省肿瘤医院1988年2月至1998年3月治疗的局限期SCLC放射治疗和化疗远期疗效资料进行分析。以期对局限期SCLC多模式的治疗方案的选择提供临床经验。,局限期小细胞肺癌化疗及放疗联合化疗的疗效,10,但几种联合治疗方案同步进行、交替进行何为最佳方案,放射治疗的,1、材料与方法,1.1 一般临床资料,局限期小细胞肺癌化疗及放疗联合化疗的疗效,11,1、材料与方法1.1 一般临床资料局限期小细胞肺癌化疗及放疗,对1988年2月到1998年3月收治的局限期小细胞肺癌患者128例,进行回顾性分析,男82例,女46例,年龄24岁74岁,中位年龄48岁,中心型108
9、例,周围型20例。患者于分期前均行胸部正侧位X光片,胸部CT,腹部B超(肝、脾、肾、肾上腺)全身骨E-CT扫描,少数病人行头部CT、MRI检查,所有病例均有病理证实,128例局限期病例按美国退伍军人医院制定的标准评定,以接受治疗开始时为准。,局限期小细胞肺癌化疗及放疗联合化疗的疗效,12,对1988年2月到1998年3月收治的局限期小细胞肺癌患者1,局限期初诊为局限于一侧胸腔转移仅限于肺门,纵隔、同侧锁骨上淋巴结,上腔静脉压迫综合征,不包括同侧胸腔积液和对侧淋巴结转移。单纯化疗42例(C)、交替治疗48例(IDG)、同步治疗38例(CON)。,局限期小细胞肺癌化疗及放疗联合化疗的疗效,13,局
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- 局限 细胞 肺癌 化疗 放疗 联合 疗效 课件
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