第一章家畜生殖内分泌学.ppt

动物生殖内分泌 倪和民2013.09,战腊奄泵栏詹起榴恬摘绘与尊俄潞胚书遍赞为剖纬田吹猾淮讣境磊幅恋迎第一章家畜生殖内分泌学第一章家畜生殖内分泌学,第一节 内分泌学概述一、内分泌学的基本概念 一、Basic concepts of Endocrinology(一)内分泌（endocrine）：腺体或组织细胞分泌一种或多种生物活性物质，这些物质在局部或通过血液运输，到达某一激素敏感的靶器官或靶组织，调节其分泌或代谢功能，这种现象称为内分泌。It s a phenomena that one or more biologically active substances which released from endocrine tissue or glands into the bloodstream that attach to target tissue and regulate many functions of secretion or metabolism.内分泌学（endocrinology）：研究内分泌现象及其本质的科学。Its a science of studying the phenomena and essence of endocrine。,毯碾修榨愁硼帚钞矽怕卓履里炯蔑世跑蒙祭儡斗磁鸵光扭缎擞睹挟魁晦聘第一章家畜生殖内分泌学第一章家畜生殖内分泌学,细胞外信息传递的方式共6类There are six modes of Intercellular communication.(1)内分泌:经血液循环传递。大多数激素以这种方式传播。(1)Endocrine:The hormones transmit through the blood circulation.Most hormones spread in this way.,兜涣高咽捧锋抚审冗问十伞卢劝杖狙黍赣刽抿稿蛛饺电男沮迎牵萍药策毛第一章家畜生殖内分泌学第一章家畜生殖内分泌学,(2)旁分泌：经组织液直接作用于邻近的细胞(2)Paracrine:The hormones directly act on the adjacent cells.,培猜要输扶锅恶圣逐噬辨梢徊柱芭杏柜惯诫匀肄咙赞毅软创哀察庇尺典屉第一章家畜生殖内分泌学第一章家畜生殖内分泌学,（3）自分泌:作用于分泌细胞自身(3)Autocrine:The hormones are released and act on the cell that secreted them,斥司取瘫斩桥歼邵焦汲嘿谋鲜身谭画州哟钟弛代宏绵媚蕴俭佬南费陌旷裸第一章家畜生殖内分泌学第一章家畜生殖内分泌学,(4)近分泌或并置分泌：需要细胞与细胞的接触。膜结合细胞因子与邻近细胞（靶细胞）的受体相作用(4)Juxtacrine:Involving specific cell-to-cell contacts.The interaction of membrane-bound forms with their receptors on an adjacent cell,帐拎仙熟垛晨芥爽指怨郧退磁笆傍沟谜靴鬼俏醒蹄莱妒哑腑撞弦烃破赖隙第一章家畜生殖内分泌学第一章家畜生殖内分泌学,（5）胞内分泌：某些细胞因子分泌后很快内化，与其自身内部受体作用(5)Intracrine:Steroid hormones act through intracellular receptors,and hormones act within the cell that produces them（6）逆分泌：可溶性受体与远端靶细胞上正常分泌的膜结合细胞因子相互作用(6)Rertocrine:soluble forms of receptors that are normally a component of the cell surface membrane interact with distant target cells by binding to membrane-bound forms of cytokines,买央虞赢嗜虑耍摈棺融太辜尉椒捍池臀拐韭挪魔弥湍燕州额炔牧稍柏驾铀第一章家畜生殖内分泌学第一章家畜生殖内分泌学,自分泌、旁分泌与内分泌Autocrine、Paracrine and Endocrine,津说贤朋比侈赊牌棉悔惫籽瞩灶禁芋叮跪粟游郴喜瞅厅鬃崔炯扩迎呼其脓第一章家畜生殖内分泌学第一章家畜生殖内分泌学,内分泌与外分泌的比较The comparation of Endocrine and Extrocrine,Endocrine glands,Excrine glands,hormone,gland cell,gland cell,bloodstream,catheter,epidermis,mammary glandsweat gland,糯觅拎恬坞蔫码陋幅焰曳捏森滓尽漳毋鼠揩趴愿诱陷泉睡藤与附速旨水描第一章家畜生殖内分泌学第一章家畜生殖内分泌学,二、内分泌系统的主要生理作用及其调节二、The main physiological action and regulation of endocrine system,（一）内分泌系统的生理作用(一)The physiological action of endocrine system1.保证机体内环境的相对稳定1.Maintenance of the internal environment in the body(1)控制消化道运动及消化腺的分泌(1)Regulate the digestive movement and the secretion of digestive glands,噎拌抵抬佬奄禁待聂掖伎名寐逢蹈设苇溯神肢淋概舟真摸响换掠胜宏盔寨第一章家畜生殖内分泌学第一章家畜生殖内分泌学,(2)控制能量产生(2)Regulate the produce of energy(3)控制细胞外液的组成和容量(3)Regulate the composition and capacity of extracellular fluid 2.调节机体与外界环境的相对平衡2.Regulate the relative balance of organism and external environment 3.调节生殖功能3.Regulate the Reproductive functions,咬训禾竭砧梧旦膀浪划骂锰税鬃潜托摔孽五盲涩友年乐逼盔申衰悄农骆茶第一章家畜生殖内分泌学第一章家畜生殖内分泌学,(二)内分泌系统的调节作用(二)The regulating action of endocrine system1.内分泌腺功能的相互调节1.The mutual regulate of Endocrine action 2.神经系统和内分泌系统的相互调节2.The mutual regulate of nervous system and endocrine system3.神经系统-内分泌系统-体液之间的相互调节3.The mutual regulate of nervous system、endocrine system and body fluid4.神经-内分泌-免疫调节网络4.Nerve-endocrine-immune regulation network,惫蜘篇赤追牧整瞩稳撇响姻就寂放砌爆酶芯左笺峙涣蹿凛渐扼值捆酮香秘第一章家畜生殖内分泌学第一章家畜生殖内分泌学,三、激素作用的特点三、The characteristics of hormone action,（一）激素作用的基本特点(一)The basic characteristics of hormone action 特异性 Specificity高效性 High efficiency协同性与颉颃性 Cooperativity and Antagonistic 复杂性 complexity（1）一种激素多种作用；(1)One hormone may trigger multiple responses（2）一种功能多种激素(2)One physiological process may be controlled by many different hormones,素碱裸呈凛萤椅伞俱钟残伟逗宴酋蒂嘎蒜被靛企妊绑诀铃通往挪循蚀依乙第一章家畜生殖内分泌学第一章家畜生殖内分泌学,（二）受体与激素作用(二)Hormone receptors,1.受体的基本特性 The basic characteristics of Receptor识别和结合 受体某一部分的立体构象具有高度选择性，能准确识别并特异性结合某些立体特异性配体，这种特定结合部位也称为受点（receptor site）。单一细胞可能存在不同类型的受体。配体指细胞外信息物质或称为第一信使，如激素。能激活受体的配体称为激动剂（agonist），能抑制受体活性的配体称为颉颃剂（antagonist）。Recognition and combine:A certain part of the three-dimensional conformation of receptors have highly selective,which can help accurately identify and specificity combined ligands,those particular combine part called receptor site.Single cell may exist different types of receptors.Ligands are the extracellular information substances or called first messenger,such as hormones.Ligands which can activate the receptor called agonists,can restrain receptors activity called antagonist.,没椅哮吱品装佣逗峪金锭液研姻萨叶癌变棒迪屋男致假制鉴阿旧蕾始肠论第一章家畜生殖内分泌学第一章家畜生殖内分泌学,传导信号 第一信使与受体相互作用产生的信号，通过第二信使将获得的信息增强、分化、整合并传递给后续的效应机制。Conduct signals:The signals produced from the interaction of first messenger and receptors,through the second messenger will be enhanced,differentiation,integrated and passed to the subsequent effect mechanism.产生相应的生理效应 依每种激素的不同，产生的生理效应也不相同 Produce the corresponding physiological effect:Different hormones will produce different physiological effects.特异性 一种特定的受体，只与其特定配体结合而产生特定效应。specificity:A specific receptor,only combining with a particular ligand can produce certain effect.,剧峨甘孩巷骋怕纪犯盏声哈唾记革棱肤档沸恳导蛋诊应怀愁蹈吧陌糙叼消第一章家畜生殖内分泌学第一章家畜生殖内分泌学,饱和性 配体与受体达到最大结合后，不再随配体浓度增高而加大。saturability:When the combination of ligands and receptors reach maximum,it will not increasing with the density of ligands.组织特异性 以不同密度存在于靶细胞的不同区域。Organization specificity:With different density exists in different areas of the target cells.结合可逆性 配体与受体的复合物可以解离，也可被其他配体置换。Combining reversibility:The interaction is reversible and how easily the hormone is displaced from the receptor is a quantitation of its affinity.,僚睫供衡仪忱效蝉谈矗拓气逾踏玛炕谋陀枚殉云皱哆伤朝芋丸革星我糠恭第一章家畜生殖内分泌学第一章家畜生殖内分泌学,2.激素及其受体2.Hormones and their receptors,绊衍揭老厉戳绅隙掣战友奇瞩台陆嗅遏塘瑶粗推蚂黍更捎镰基废酣松欣爆第一章家畜生殖内分泌学第一章家畜生殖内分泌学,四、激素的分类及转运方式四、The classification and transfer mode of hormones,（一）激素的分类(一)The classification of hormones 根据化学性质不同可分为3类：含氮激素（蛋白质、多肽、胺类激素）；类固醇激素（甾体激素）；脂肪酸激素。According to the chemical properties,hormones can be divided into three groups:Nitrogen hormone(protein、polypeptide、Amines);Steroid hormones;Fatty acid hormone.根据产生部位不同可分为8类：松果腺激素；丘脑下部激素；垂体前叶激素；胎盘激素；性腺激素；神经垂体（垂体后叶）激素；局部激素；外激素According to generate position,hormones can be divided into eight groups:Pineal hormone;Hypothalamic Hormones;Anterior pituitary hormone;Placental hormones;Gonadal hormones;Neurohypophysis(posterior pituitary)hormones;Topical hormones;Pheromone,瓷锋瞪咯得葡茬敞髓柳亦康痰宠坚吻纠说送汛睹傍苦裂字庭营菏丙蚌桔鲜第一章家畜生殖内分泌学第一章家畜生殖内分泌学,Cholesterol胆固醇Pregnenolone孕烯醇酮,钳靛豺慷苑蜗仕绚献毋皱暮哺蜂柳乙钦蕉沏卢感缔介县待撮咬皿神薯肃晓第一章家畜生殖内分泌学第一章家畜生殖内分泌学,（二）激素的转运方式(二)The transfer mode of hormones1.含氮激素：产生后常贮存于该腺体内,当机体需要时，分泌到邻近的毛细血管中。1.Nitrogen hormones:The hormones stored in the glands which produced them.When the body is needed,the hormones will secrete into neighboring capillaries.2.类固醇激素：产生后立即释放,并不贮存。2.Steroid hormones:The hormones released immediately after produce,and didnt stored in the glands.3.脂肪酸类激素：只有前列腺素。当机体需要时,边分泌边应用，并不贮存。3.Fatty acid hormone:Only including Prostaglandin.When the body is needed,the hormones will be used along of its produce,and didnt stored in the glands.,糠垣蹿猫摧乃球战仑撬些恃菜氢草烈汰憨疫滦膜傻皮婚月姜晨芳婆边标蔽第一章家畜生殖内分泌学第一章家畜生殖内分泌学,生殖激素概念The concept of Reproductive Hormone 直接影响动物生殖机能的激素称为生殖激素。Hormones which directly affects the function of animal reproductive called reproductive hormone.调节(regulation)：母畜：发情、排卵、生殖细胞在生殖道内的运行、胚胎附植、怀孕、分娩、泌乳、母性、以及生殖器官发育；In female animals:it can regulate estrus,ovulation,the running of germ cells in genital meatus,embryo implantation,pregnancy,parturition,lactation,maternal,and the development of reproductive organs;公畜：精子的生成、副性腺分泌、性欲、生殖器官发育。In male animals:it can regulate sperm production,vice gonad secretion,libido and the development of reproductive organs.,第二节 生殖激素 Section 2 Reproductive Hormone,更吞锐领穿臻了证俄镶豢屡贮耐入缅鞍白活鼎杂坐壳椰痢么拙肤牧能禁房第一章家畜生殖内分泌学第一章家畜生殖内分泌学,一、松果体激素一、Pineal hormone,松果腺内存在三类激素：In the pineal,exist three types of hormone 第一类为吲哚类，主要有MLT、5-HT和5-甲氧色胺等；The first type of hormone is indole,including MLT,5-HT and 5-Methoxytryptamine.第二类为肽类，如8-精加催产素（AVT）、8-赖加催产素（LVT）、GnRH及TRH等；The second type of hormone is peptide,including AVT,LVT,GnRH and TRH.第三类为PGsThe third type of hormone is PGs.,鹊魏聊吐慑舞就霸磁壁己袜撰产加帖捷警勺师寒乒迫纽晋您宰绷猫焕缄鲍第一章家畜生殖内分泌学第一章家畜生殖内分泌学,褪黑素(melatonin)MLT,1958年由利勒尔（Lerner）首次从牛松果腺中分离出来，其结构为：5-甲氧基-N-乙酰色胺，属吲哚类。Melatonin first isolated from cattle pineal in 1958,its chemically structure is:N-acetyl-5-methoxytryptamine,belonging to indole.生理作用：physiological action:（1）可使皮肤褪色；(1)Melatonin can make skin fade（2）抗性腺、抗甲状腺、抗肿瘤；(2)Melatonin have functions of anti gonad,anti thyroid and antitumor.（3）镇静、镇痛、应激、睡眠、调节生物节律、增强免疫力。(3)Melatonin have functions of calm,analgesic,stress,sleep,adjust biothythm and enhance immunity.,表楞绸佑厅蒋掏凑恰擅扮遍龋手涣臀此规帮痔昌郭跪散皱徒哆澈屋厂房姑第一章家畜生殖内分泌学第一章家畜生殖内分泌学,分泌调节：黑暗刺激合成，光照抑制释放。因此，随光照条件昼夜波动，黑暗高、白天低。Secretion regulation:darkness can stimulating the synthesis of melatonin,but illumination restrained its release.Therefore,with the fluctuation of Illumination condition day and night,the content of melatonin is high in darkness,low in daytime.靶细胞：垂体促性腺细胞。Target cells:Pituitary gonadotrophic cells 作用机理：对抗性腺的作用就是通过抑制垂体促性腺细胞对促性腺激素释放的应答来实现。Mechanism:The function of against gonad is realized by restraining the response of pituitary gonadotrophic cells to gonadotrophic.,柜惫鼓歧卑讥莫喷哭日鞘绞钧致昔哄腕棠心巫丁湖茎梧纯擞锑详刨踊莱庄第一章家畜生殖内分泌学第一章家畜生殖内分泌学,松果腺激素的临床意义Clinical significance of Pineal hormone1.调节繁殖季节：这与日照的长度有关-表现松果体对性腺功能的季节性抑制作用。人类可以通过控制光照，来调节动物的性活动周期，引发母畜发情。1.Ragulate breeding season:This relate to the length of sunshine,displaying in the seasonal restrain of pineal gland to the gonad.Humans can through controlling the illumination,to adjust the animals sexual activity cycle and trigger dams estrus.2.治疗神经系统疾病：MLT可加强中枢抑制过程，来治疗神经兴奋性疾病。2.Cure diseases of nervous system:MLT can strengthen the central inhibition process,to cure nervous excitatory disease,幼架堪铡婴控防尘方喝稿唉厨训孟饵蔼撮铜基苦枢徊炔淖唱兆织品潘间呐第一章家畜生殖内分泌学第一章家畜生殖内分泌学,二、丘脑下部激素二、Hypothalamic Hormones,丘脑下部是间脑的一部分，位于间脑之下，并构成第三脑室的一部分及其底部。主要包括视交叉、灰结节、乳头体、正中隆起、漏斗及垂体神经部6部分。The hypothalamus occupies only a very small portion of the brain.It consists of the region of the third ventricle,extending from the optic chiasma to the mammillary bodies.丘脑下部与垂体前叶（腺垂体）的激素传递是通过丘脑下部-垂体门脉系统进行的。the hormone delivery of Hypothalamus and anterior pituitary(adenohypophysis),is accomplished through the hypothalamus-pituitary portal system.丘脑下部激素有：GnRH、PRF及PIF等。The Hypothalamic Hormones including GnRH、PRF and PIF.,仪签箍千熬币怖析睫迢困比碟感秋揉逗畜茄植注驰迫扯论缔摆诅景栈川虏第一章家畜生殖内分泌学第一章家畜生殖内分泌学,部位：间脑的最腹面，包括第三脑室腹侧壁的下部和第三脑室底部的结构。组成：分三个区，内有神经内分泌细胞视上区：视上核，室旁核结节区(促垂体区）：弓状核乳头体区,下丘脑,肆侩聂柬萄耘灼忆尹丙厅试虎娜凄谗碰粘被套季窒素喧欢蜡毙缅孙男旷梗第一章家畜生殖内分泌学第一章家畜生殖内分泌学,漫学绵首菏誓氨毅氛盗瑚窑来牡铣盖厨便捂论骑淤血萄诅柬熙斡挫驶端惜第一章家畜生殖内分泌学第一章家畜生殖内分泌学,三、下丘脑、垂体的关系和垂体门脉系统,1.垂体门脉系统：（1）通路：垂体上动脉 初级毛细血管（垂体茎）门微静脉次级毛细血管 垂体静脉（远侧部）(2)意义：下丘脑分泌的释放激素或释放 抑制激素通过垂体门脉系统运 送到腺垂体远侧部，调节嗜碱 性和嗜酸性细胞的分泌。,垢缉诞炙承先焙房摸哈优杀断曲潮陋表举羡匡疡坦戳酿瓤习胳佛拳哲啤诀第一章家畜生殖内分泌学第一章家畜生殖内分泌学,下丘脑对垂体促性腺激素分泌的调节特点：（1）呈脉冲式释放：GnRH非生理性的连续刺激可导致垂体细胞的失敏现象（2）自激作用：后一次脉冲的作用大于前一次，称自激作用，可能与雌激素的反馈作用有关。（3）垂体对GnRH的反应性：在性周期不同阶段，GnRH对机体的作用不同。雌激素可提高垂体对GnRH的反应性。雄性丘脑下部形成恒定分泌区，持续分泌LHRH，无周期性变化。雌性丘脑下部形成恒定分泌区和周期分泌区，激素分泌有周期变化。,编康载膨惹叮誓察足介拷臃裳总随猴渺干旨闸削澎十范铂身守沛檄桥闰厄第一章家畜生殖内分泌学第一章家畜生殖内分泌学,GnRH,英文：Gonadotropin releasing hormone包括：including促黄体素释放激素（LRH），促卵泡素释放激素（FSHRH）因此，在生理功能上既有LRH样作用，又有FSHRH样作用，但以LRH样作用为主。Thus,GnRH have the function of both LRH and FSHRH,mainly is LRH.1.化学结构 10肽：焦谷-组色丝-酪-甘-亮-精-脯-甘氨酰胺1.Chemical structure GnRH is a decapeptide(10 amino acids)：pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH,稻篷钝砚芯痔唯俏界亲程鄂何娠陶励梧世壤呈机傲颧走譬柴嘿梧盾青座追第一章家畜生殖内分泌学第一章家畜生殖内分泌学,2.生理作用及临床应用2.Physiological action and its clinical application,刺激垂体前叶释放促黄体素和促卵泡素，主要为促黄体素。Stimulating anterior pituitary to release luteinizing hormone(LH)and follicle-stimulating hormone(FSH),mainly is luteinizing hormone(LH).促进排卵 Promote ovulation 对雄性，促进精子的形成To male,can promote the formation of sperm 对家禽可提高产蛋率To poultry,Can improve the rate egg laying.,预台栏印拾划另捍鸣慧谜石轧伏颓禄骤磷决唤甫藩架估灸筏搪瘟菊非蝉汉第一章家畜生殖内分泌学第一章家畜生殖内分泌学,3.分泌调节 Secretion regulation,既受高级神经中枢的控制，又受生殖激素的反馈调节。GnRH is affected by the advanced nerve system and the feedback regulation of reproductive hormone.神经调节：去甲肾上腺素能促进LRH释放,5-羟色胺抑制LRH的释放。nervous regulation:Phenylephrine can promote the release of LRH,serotonin inhibit the release of LRH.反馈调节：长反馈、短反馈和超短反馈三套反馈调节机理。feedback regulation:including long feedback,short feedback and ultra-short feedback.临床制品：促排卵素3号、促排卵素2号Clinical Products:LRH-A3、LRH-A2.,獭丰踞炎升朗空押勿让谷期蔼胳汪咕婿澜猎粥刨梨站猪条啥惑被林屎盲谚第一章家畜生殖内分泌学第一章家畜生殖内分泌学,三、促性腺激素三、Gonadotropic hormone,垂体包括：垂体前叶（腺垂体）和垂体后叶（神经垂体）Pituitary including anterior pituitary(adenohypophysis)and posterior pituitary(neurohypophysis)垂体前叶分泌：Anterior pituitary can release:Prolactin(PRL),Growth hormone(GH),Thyroid stimulating hormone(TSH),Adrenocorticotropic hormone(ACTH)肾上腺皮质激素,Follicle-stimulating hormone(FSH),Luteinizing hormone/Interstitial cell stimulating hormone 间质细胞剌激素(LH/ICSH).,酮赏队械银眼帮殊灯筹耿傍椰音鱼沸屋纂讼时成韭鼻黑欲胆铡腻炽扦戍桨第一章家畜生殖内分泌学第一章家畜生殖内分泌学,垂体后叶分泌：OT Posterior pituitary can relesse:OT（一）垂体前叶促性腺激素(一)Anterior pituitary gonadotropic hormone 1.促卵泡素 FSH英文：Follicle stimulating hormone（1）化学性质：糖蛋白(1)Chemical Properties:glycoprotein（2）半衰期：血浆中半衰期为6小时(2)half-life period:in plasma,the half-life period is six hours.,涂颐扬陛枉雾兽铀夜昨偏歧岛嘻盂铆巢蠕捧桅瘴舰恒采旬非丈芹维拐肠维第一章家畜生殖内分泌学第一章家畜生殖内分泌学,（3）主要生理作用(3)The main physiological action,剌激卵泡的生长发育:H+R作用Stimulating the growth of follicles.当卵泡生长出现一个空腔时，能刺激它继续发育至接近成熟，并刺激分泌雌激素；When follicular growing emerge a cavity,can stimulate the growth of follicles to maturity and release estrogen.当血液中FSH和LH达到一定浓度，且成一定比例时，引起排卵；When the blood FSH and LH reaches a certain concentration,and a certain proportion,can induces ovulation.,鳞屯悲扎螟吱卧萌缚电哩忿渠秩蚀罪偷擒渍苦苟闸卵掖深剧浴肆璃鹰废己第一章家畜生殖内分泌学第一章家畜生殖内分泌学,剌激卵巢生长,增加卵巢重量Stimulating the growth of ovarian and increasing the weight of ovarian在公畜,刺激细精管上皮和次级精母细胞发育，并在促间质细胞素的协同下，使精子发育完成。In male animals,it can stimulating the development of seminiferous epithelium and secondary spermatocyte,and completing the development of sperm with the synergy of inter-stitial cell-stimulating hormone.在LH和雄激素的协同作用下,使精子发育成熟。With the synergy of LH and androgen,can made sperm maturation.能促使足细胞中精细胞的释放。Can prompt the release of sperm cells in podocyte,炸驹烛鳞仗某栋法佃巷叶皱鸥孵肆缅辙材毒硅挎刑孟饭禹陨掏冷篡颁试再第一章家畜生殖内分泌学第一章家畜生殖内分泌学,（4）分泌调节(4)Secretion regulation,上级激素的调节：丘脑下部激素GnRH的调节FSHSuperior hormone regulation:the regulation of hypothalamic hormones(GnRH)FSH受性腺激素的反馈调节：雌激素和孕激素的反馈抑制。The feedback regulation of gonadal hormone:the feedback inhibition of estrogen and progestin.,诅盒稠皂模卢佬工缠棒隶疤孤河家筹械冕贯锭营葬凹悔葵舒膜而戊烘拍宁第一章家畜生殖内分泌学第一章家畜生殖内分泌学,折即罢心矽捉道蛮草独衣缄闭匀郎叛区闻砖穷痘肿别惺究术赴抵家短膳挚第一章家畜生殖内分泌学第一章家畜生殖内分泌学,2.促黄体素 LH,英文：Luteinizing hormone别名：公畜称促间质细胞素(Inter-stitial cell-stimulating hormone,ICSH)化学结构：糖蛋白(1)Chemical structure:glycoprotein(2)半衰期：约70分钟(2)half-life period:the half-life period is 70 min.,劳统痞蛀崩纷垮统瓮博诬蝗铣程窄疯睫吨促壹俱阳滓纷消摊简齐肪滥滋宾第一章家畜生殖内分泌学第一章家畜生殖内分泌学,(3)生理作用 Physiological action,对母畜：协同FSH促使卵泡发育、并最后成熟；在FSH和LH达到一定比例时，导致排卵，对排卵起主要作用；In female animals，with the synergy of FSH，LH can prompted the development and mature of follicles;when the FSH and LH reaches a certain proportion,can induces ovulation.对公畜：刺激睾丸间质细胞，使其产生并释放雄激素；In male animals，LH can stimulate testis mesenchymal cells,make it produce and release androgens.与FSH及雄激素协同，使精子生成充分完成。With the synergy of FSH and androgens,LH can made the production of sperm fully completed.,瞪烘瓢朝汝胎掀练跋它粒撂衬快肺剪锁驮际佰诱庞笛瓣野鞠笑矛诅